Mechanism of activity and toxicity of Nystatin-Intralipid
نویسندگان
چکیده
منابع مشابه
Mechanism of activity and toxicity of Nystatin-Intralipid.
A novel lipid formulation of Nystatin (NYT), Nystatin-Intralipid (NYT-IL), which was found to be more active and less toxic in vitro and in vivo, was developed in our laboratory. The aim of the present study was to explore the possible mechanisms underlying its biological activity. To assess mechanisms affecting fungal cells we conducted the following experiments: killing kinetics, scanning and...
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comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
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15 صفحه اولPharmacokinetics, tissue distribution and immunomodulatory effect of intralipid formulation of nystatin in mice.
OBJECTIVES We developed a novel lipid formulation of nystatin suitable for parenteral administration, nystatin-intralipid (NYT-IL), with antifungal activity and reduced toxicity in mice. We investigated the pharmacokinetics, tissue distribution and immunomodulatory effect of NYT-IL in mice. METHODS Nystatin levels in serum and organs were determined using HPLC after NYT-IL or nystatin adminis...
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ژورنال
عنوان ژورنال: Medical Mycology
سال: 2013
ISSN: 1369-3786,1460-2709
DOI: 10.3109/13693786.2012.731712